This report was co-published with the South African Medical Association, and the South African Pharmaceutical Research Foundation. The original version was posted in November 2023.
ABOUT THE AUTHOR
Dr. David M. Mardan
Pharmaceutical and Nourishing Specialist, Pharmacology Unit, South African National University, Cape Town
Mardan has over 35 years of experience, and has been a member of the International Nourish Society (INS). In his career, he has worked for several different companies, such as Pfizer, Mylan and Sun Pharmaceutical. He is currently a member of the Medical Council of South Africa, the Pharmaceutical Society of the Western Cape, and the South African Medical Association.
ABSTRACT
Sildenafil citrate, the active ingredient in Viagra, is the first oral treatment for erectile dysfunction (ED). It is used to treat erectile dysfunction in men over 50. The drug has been shown to improve sexual function, with more satisfying erections and improved erections, especially in men who suffer from erectile dysfunction (ED). In patients with erectile dysfunction, the efficacy of the drug may be questionable because of the low rates of adverse events reported in clinical trials. However, in this study, we show that sildenafil citrate improves the efficacy of sildenafil citrate in a rat model of premature ejaculation.
The mechanism by which sildenafil improves ED has not yet been established. The mechanism involves the inhibition of the phosphodiesterase type 5 (PDE5) enzyme in the penis, which leads to increased blood flow into the penis, facilitating an erection. This is believed to be the primary reason for the improved quality of erection in men with ED.
The drug has been shown to improve blood flow to the penis, increasing blood flow to the erectile tissue, resulting in an erection. It may also improve blood circulation and exercise capacity in the area.
The safety and efficacy of sildenafil citrate (Viagra), the active ingredient in Viagra, have been evaluated in male patients with erectile dysfunction. In a study, 100 patients with ED received either sildenafil citrate 50 mg orally or placebo for 5 days.
The study included 90 patients with ED who had either an erection lasting for more than 4 hours or no erection at all. After 5 days, patients were randomly assigned to either sildenafil citrate 50 mg orally or placebo. Patients who received sildenafil citrate 50 mg orally or placebo reported a mean of four attempts per day, and those who received sildenafil citrate 50 mg orally reported four attempts per day. The primary end point was the number of attempts per day for each of the four treatment groups. The mean number of attempts for each treatment group was 3.8. The mean number of attempts for the sildenafil citrate 50 mg orally group was 4.6. The mean number of attempts for the placebo group was 3.6. The mean number of attempts for the sildenafil citrate 50 mg orally group was 3.4 and the mean number of attempts for the placebo group was 3.2. The percentage of attempts for each of the treatment groups were calculated.
The results of the study showed that the mean number of attempts per day for the sildenafil citrate 50 mg orally group was four, while the number of attempts for the placebo group was two. This finding indicates that sildenafil citrate may have a positive effect on the ability of erectile tissue to respond to sexual stimulation.
The safety and efficacy of sildenafil citrate in patients with ED have been evaluated in a rat model of premature ejaculation (PE). In this study, 100 male subjects with PE were treated with sildenafil citrate 50 mg orally for 5 days. The study was conducted in two groups: (1) sildenafil citrate 50 mg orally or placebo; and (2) sildenafil citrate 50 mg orally or placebo, with the doses of 5 and 25 mg administered.
The results of the study showed that sildenafil citrate 50 mg orally or placebo produced a statistically significant decrease in mean number of attempts per day (P < 0.05) and mean number of attempts per day (P < 0.001) for the sildenafil citrate 50 mg orally or placebo group.
IMPORTANT NOTICE: Please be aware, prior to sale, you are advised to have a short phone call consultation with our Pharmacist. Automatic purchase consents the Pharmacist to give you a quick call.
Viagra Connect is available without a Prescription but requires a brief consultation with the Pharmacist. It is available in a 4 pack or an 8 pack. Viagra Connect contains Sildenafil 50mg which works by relaxing the penis blood vessels, allowing blood to flow when you get aroused causing erections and potency. Viagra Connect will only help men become erect if you are aroused. Only for adult use, men 18 years plus.
How to be taken:
VIAGRA CONNECT is not to be taken if:
Please read instructions carefully provided.
Viagra Connect is a fast acting drug for erectile dysfunction which can last up to 4 hours and takes effect within 30 minutes after administration.
Sildenafil Citrate 50 mg Tablets: This tablet is specifically formulated to treat the symptoms of erectile disfunction and is highly effective in treating it, the most common sexual disorder affecting men over the age of 40 years. Provides a solution to erectile dysfunction in men who suffer from impotence due to conditions such as heart disease or diabetes, or who have problems with their physical or mental health.
Viagra Connect ensures fast and effective results that last as long as 36 hours and come without side effects. It works by relaxing the blood vessels in the penis, allowing blood to flow into the phallus when you get sexually excited and causing the desired stiffness.
AddisonWarning: Viagra Connect is available only with a prescription so be sure to talk to your doctor before you take it you must talk to a doctor before taking it. Avoid taking taking medicinescessive with other medications as they may affect your health.Viagra Connect is a new erectile dysfunction treatment which does not require a prescription.
The first of its kind, Viagra Connect is a safe and discreet over-the-counter medication that can legally be bought online without a trip to your doctor.
We need to ensure that this medicine is suitable for the person it is intended for. Therefore, it should only be purchased by the person taking it.
A pharmacist may need to contact you by phone before providing the product. If they cannot reach you within 72 hours, your order may be delayed, or this item may be cancelled from your order.
Please ensure your contact details are correct before ordering this medicine.Suitable forViagra Connect is for men 18 years and older who have difficulty getting and/or keeping an erection hard enough for sex
Age RestrictionYou must be at least 18 years old to purchase this product.
Directions for use:Please read the enclosed leaflet carefully before use.
• take 1 tablet approximately one hour before sexual activity• swallow tablet whole with water• do not take more than 1 tablet a dayViagra Connect starts to work within 30-60 minutes. You may take it up to 4 hours before sexual activity.
Hazards and Cautions
Do NOT take if you:
Talk to your pharmacist or doctor before taking if you:
As with all medicines, please ensure you read the patient information leaflet before taking this item.
CA:As with all medicines, Viagra Connect may cause a dangerous fall in to blood when taken near high altitudes, or when very low levels of salt are absorbed. This risk is increased when you are in favorable conditions for sweating and when taking other hormone-based medications.
Do not use this medicine if you are also taking other patients’ medicines called “ CYP2C19 Inhibitors,” which aretube-like tablets used to treat conditions linked to certain liver disease or you have been advised by your doctor to avoid sexual activity because of problems with your heart or blood vessels.
Please ensure you read the enclosed patient information information before taking this itemHuman Growth Hormone (hBSA) ( levels of hBSA in blood)Viagra Connect works in the penis by increasing blood flow to the penis.
This medicine for individuals under 18 is used for the short-term treatment of erectile dysfunction. Extended-release tablets may help reduce the frequency and severity of side effects.
For further information see.
UseesySee also:NeedlesViagra Connect contains painkillerscribu. This medicine used to treat a very stiff or rigid penis can also cause severe side effects. Should you need to use this medicine, please read the enclosed patient information leaflet before use.
Viagra has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.
Common side effects reported from Viagra use include:
More severe side effects include:
If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.
As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Viagra. Viagra can interact with bodily substances, causing potentially serious adverse reactions.
Specifically, you should inform your health care provider of any nitrate medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.
In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.
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As with any medication, Viagra can cause some side effects. The most common side effects are:
As with all medication, Viagra can cause potentially serious adverse reactions that require immediate medical attention.
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